A new on-chip whole blood/plasma separator driven by asymmetric capillary forces
Lab on a Chip, ISSN: 1473-0189, Vol: 13, Issue: 16, Page: 3261-3267
2013
- 52Citations
- 116Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations52
- Citation Indexes52
- 52
- CrossRef45
- Captures116
- Readers116
- 116
- Mentions1
- References1
- 1
Article Description
A new on-chip whole blood/plasma separator driven by asymmetric capillary forces, which are produced through a microchannel with sprayed nanobead multilayers, has been designed, fabricated and fully characterized. The silica nanobead multilayers revealing as superhydrophilic surfaces have been fabricated using a spray layer-by-layer (LbL) nano-assembly method. This new on-chip blood plasma separator has been targeted for a sample-to-answer (S-to-A) microfluidic lab-on-a-chip (LOC) toward point-of-care clinical testing (POCT). Effective plasma separation from undiluted whole blood was achieved through the microchannel which was composed of asymmetric superhydrophilic surfaces with a 10 mm hydrophobic patch. Blood cells were continuously accumulated over the hydrophobic patch while the blood plasma was able to flow over the patch. Therefore, the blood plasma was successfully separated from the whole blood throughout the accumulated blood cells which worked as a so-called 'self-built-in blood cell microfilter'. The separated plasma was approximately 102 nL from a single drop of 3 μL whole blood within 10 min, which is very suitable for single-use disposable POCT devices. © 2013 The Royal Society of Chemistry.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84880385170&origin=inward; http://dx.doi.org/10.1039/c3lc50370d; http://www.ncbi.nlm.nih.gov/pubmed/23793507; https://xlink.rsc.org/?DOI=c3lc50370d; https://dx.doi.org/10.1039/c3lc50370d; https://pubs.rsc.org/en/content/articlelanding/2013/lc/c3lc50370d
Royal Society of Chemistry (RSC)
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