Liposome surface functionalization based on different anchoring lipids via Staudinger ligation
Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 12, Issue: 8, Page: 1237-1244
2014
- 55Citations
- 24Usage
- 60Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations55
- Citation Indexes55
- 55
- CrossRef52
- Usage24
- Abstract Views24
- Captures60
- Readers60
- 60
Article Description
Liposome surface functionalization facilitates numerous potential applications of liposomes, such as enhanced stability, bioactive liposome conjugates, and targeted drug, gene and image agent delivery. Anchoring lipids are needed for grafting ligands of interest and play important roles in ligand grafting density, liposome stability, and liposome chemical and physical characteristics as well. In this report, glyco-functionalized liposome systems based on two kinds of anchoring lipids, phosphatidylethanolamine (PE) and cholesterol (Chol), were prepared by post chemically selective functionalization via Staudinger ligation. The size and stability of the liposomes were confirmed by dynamic light scattering (DLS). Particularly, the impact of anchor lipids on the stability of glyco-functionalized liposomes was investigated by comparing two different anchor lipids, namely Chol-PEG-TP and DSPE-PEG -TP. In addition, the encapsulation and releasing capacity of the glycosylated liposome based on the two anchoring lipids were investigated by entrapping 5,6-carboxyfluorescein (CF) dye and monitoring the fluorescence leakage, respectively. Furthermore, the density and accessibility of grafted carbohydrate residues on the liposome surface were evaluated for the two anchoring lipid-derived liposomes with lectin binding, respectively. © 2014 The Royal Society of Chemistry.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84893255768&origin=inward; http://dx.doi.org/10.1039/c3ob41721b; http://www.ncbi.nlm.nih.gov/pubmed/24413731; https://xlink.rsc.org/?DOI=c3ob41721b; https://engagedscholarship.csuohio.edu/scichem_facpub/157; https://engagedscholarship.csuohio.edu/cgi/viewcontent.cgi?article=1158&context=scichem_facpub; https://dx.doi.org/10.1039/c3ob41721b; https://pubs.rsc.org/en/content/articlelanding/2014/ob/c3ob41721b; http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/c3ob41721b; https://pubs.rsc.org/en/content/articlepdf/2014/ob/c3ob41721b; https://pubs.rsc.org/en/content/articlehtml/2014/ob/c3ob41721b; https://pubs.rsc.org/en/content/articlelanding/2014/OB/c3ob41721b; http://xlink.rsc.org/?DOI=c3ob41721b; http://pubs.rsc.org/en/content/articlepdf/2014/OB/C3OB41721B; http://pubs.rsc.org/en/content/articlepdf/2014/ob/c3ob41721b; http://pubs.rsc.org/en/content/articlelanding/2014/ob/c3ob41721b; http://pubs.rsc.org/en/content/articlehtml/2014/ob/c3ob41721b; http://engagedscholarship.csuohio.edu/scichem_facpub/157
Royal Society of Chemistry (RSC)
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