Imidazole as organocatalyst for multicomponent reactions: Diversity oriented synthesis of functionalized hetero- and carbocycles using in situ-generated benzylidenemalononitrile derivatives
RSC Advances, ISSN: 2046-2069, Vol: 4, Issue: 8, Page: 3732-3741
2014
- 87Citations
- 30Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
The multicomponent reaction of malononitrile, aldehyde and a third reaction partner such as naphthol/4-hydroxycoumarine/2-hydroxynaphthoquinone/kojic acid/enolizable ketone or thiol in the presence of imidazole as an organocatalyst provides very interesting molecular diversity. In an almost neutral reaction medium, this protocol provides easy access to highly functionalized 2-amino-4H-chromenes, dienes and 2-amino pyridines using in situ-generated aryl/alkylylidenemalononitrile derivatives obtained from the reaction of aldehydes and malononitrile along with various nucleophiles under reflux conditions in ethanol. This methodology is useful for the easy access of a wide range of structurally diverse functionalized molecules having potential application in biological systems. © 2013 The Royal Society of Chemistry.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84890855355&origin=inward; http://dx.doi.org/10.1039/c3ra45252b; http://xlink.rsc.org/?DOI=C3RA45252B; http://pubs.rsc.org/en/content/articlepdf/2014/RA/C3RA45252B; https://xlink.rsc.org/?DOI=C3RA45252B; https://dx.doi.org/10.1039/c3ra45252b; https://pubs.rsc.org/en/content/articlelanding/2014/ra/c3ra45252b
Royal Society of Chemistry (RSC)
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