High resolution ion mobility-mass spectrometry for separation and identification of isomeric lipids
Analyst, ISSN: 1364-5528, Vol: 140, Issue: 20, Page: 6904-6911
2015
- 170Citations
- 151Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations170
- Citation Indexes170
- 170
- CrossRef169
- Captures151
- Readers151
- 151
Article Description
Lipidomics is a particularly difficult analytical challenge due to the number and importance of isomeric species that are known or postulated in biological samples. Current separation and identification techniques are too often insufficiently powerful, slow or ambiguous. High resolution, low field ion mobility coupled to mass spectrometry is shown here to have sufficient performance to represent a new alternative for lipidomics. For the first time, drift-tube ion mobility separation of lipid isomers that differ only in position of the acyl chain, position of the double bond or double bond geometry is demonstrated. Differences in collision cross sections of less than 1% are sufficient for baseline separation. The same level of performance is maintained in complex biological mixtures. More than 130 high-precision reduced mobility and collision cross section values were also determined for a range of lipids. Such data can be the basis of a new lipidomics workflow, as the appropriate libraries are developed.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84942636142&origin=inward; http://dx.doi.org/10.1039/c5an00838g; http://www.ncbi.nlm.nih.gov/pubmed/26312258; http://xlink.rsc.org/?DOI=C5AN00838G; http://pubs.rsc.org/en/content/articlepdf/2015/AN/C5AN00838G; https://xlink.rsc.org/?DOI=C5AN00838G; https://dx.doi.org/10.1039/c5an00838g; https://pubs.rsc.org/en/content/articlelanding/2015/an/c5an00838g
Royal Society of Chemistry (RSC)
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