Biocompatible polymer-metal-organic framework composite patches for cutaneous administration of cosmetic molecules
Journal of Materials Chemistry B, ISSN: 2050-750X, Vol: 4, Issue: 43, Page: 7031-7040
2016
- 38Citations
- 76Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations38
- Citation Indexes38
- 38
- CrossRef33
- Captures76
- Readers76
- 76
Article Description
Despite increasing interest in metal-organic frameworks (MOFs) in the biomedical field, developing specific formulations suitable for different administration routes is still a main challenge. Here, we propose a simple, fast and bio-friendly press-molding method for the preparation of cutaneous patches based on composites made from the drug nanocarrier MIL-100(Fe) and biopolymers. The physicochemical properties of the patches (structure, hydration, bioadhesive and swelling properties), as well as their encapsulation and release capabilities (both in ex vitro and ex vivo models), were evaluated using active ingredients such as the challenging cosmetic liporeductor, caffeine, and the model analgesic and anti-inflammatory drug, ibuprofen. In particular, very high caffeine loadings were entrapped within these cutaneous devices with progressive releases under simulated cutaneous physiological conditions as a consequence of the swelling of the hydrophilic patches. Despite the absence of any cutaneous bioadhesive character, these patches provided progressive and suitable permeation of their cosmetic cargo through the skin, interestingly reaching the targeted adipose tissue. This makes these cosmetic-containing composite MOF-based patches promising candidates for new cutaneous devices in cosmetic applications.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84994588741&origin=inward; http://dx.doi.org/10.1039/c6tb01652a; http://www.ncbi.nlm.nih.gov/pubmed/32263570; http://xlink.rsc.org/?DOI=C6TB01652A; http://pubs.rsc.org/en/content/articlepdf/2016/TB/C6TB01652A; https://xlink.rsc.org/?DOI=C6TB01652A; https://dx.doi.org/10.1039/c6tb01652a; https://pubs.rsc.org/en/content/articlelanding/2016/tb/c6tb01652a
Royal Society of Chemistry (RSC)
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