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Weak, bidentate chelating group assisted cross-coupling of C(sp)-H bonds in aliphatic acid derivatives with aryltrifluoroborates

Chemical Communications, ISSN: 1364-548X, Vol: 54, Issue: 90, Page: 12766-12769
2018
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Article Description

A protocol of Pd(ii)-catalyzed, weak bidentate directing group assisted β-C(sp)-H activation/cross-coupling with organoboron reagents has been achieved, affording arylation of aliphatic acid derivatives that contain α-hydrogen atoms in moderate to good yields. The potential of this method for an asymmetric β-C(sp)-H arylation via desymmetrization was also presented.

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