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Probing the determinants of porosity in protein frameworks: Co-crystals of cytochrome: C and an octa-anionic calix[4]arene

Organic and Biomolecular Chemistry, ISSN: 1477-0520, Vol: 18, Issue: 2, Page: 211-214
2020
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Article Description

Sulfonato-calix[n]arenes (sclx) are promising tools to generate crystalline protein frameworks. We report, for the first time, a lower rim functionalised octa-anionic calix[4]arene (sclxmc) in complex with proteins. Two crystal structures of sclxmc bound to yeast or horse heart cytochrome c (cytc) are described. Highly porous honeycomb or tubular assemblies were obtained with yeast or horse cytc, respectively. Related frameworks were obtained previously with sclx and sclx but not with sclx, suggesting that the ligand charge is a determining factor.

Bibliographic Details

Alex, Jimi M; Brancatelli, Giovanna; Volpi, Stefano; Bonaccorso, Carmela; Casnati, Alessandro; Geremia, Silvano; Crowley, Peter B

Royal Society of Chemistry (RSC)

Biochemistry, Genetics and Molecular Biology; Chemistry

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