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Stable π-radical nanoparticles as versatile photosensitizers for effective hypoxia-overcoming photodynamic therapy

Materials Horizons, ISSN: 2051-6355, Vol: 8, Issue: 2, Page: 571-576
2021
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Article Description

We report the first demonstration using a stable π-radical as a versatile photosensitizer for hypoxia-overcoming photodynamic therapy. After self-assembling the radical molecules into radical nanoparticles (NPs), the NPs show good water dispersibility, good biocompatibility, broad near-infrared (NIR) absorption and emission at ∼800 nm. Significantly, the radical NPs remain stable in various biological mediums, after 100 days exposure to the ambient environment, and even after long-term laser irradiation, which is superior to many reported radical-based materials. More importantly, upon 635 nm laser irradiation, sufficient superoxide radical (O2-) generation and in vitro cytotoxicity were observed addressing the most important hurdle for successful PDT in the oxygen-deficient tumor microenvironment. In addition, the radical NPs are also demonstrated to have effective in vivo PDT efficacy, and excellent biosafety.

Bibliographic Details

Cui, Xiao; Lu, Guihong; Dong, Shengzhi; Li, Shengliang; Xiao, Yafang; Zhang, Jinfeng; Liu, Yanhong; Meng, Xiangmin; Li, Feng; Lee, Chun-Sing

Royal Society of Chemistry (RSC)

Materials Science; Engineering; Chemical Engineering

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