Stable π-radical nanoparticles as versatile photosensitizers for effective hypoxia-overcoming photodynamic therapy
Materials Horizons, ISSN: 2051-6355, Vol: 8, Issue: 2, Page: 571-576
2021
- 53Citations
- 18Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations53
- Citation Indexes53
- 53
- CrossRef51
- Captures18
- Readers18
- 18
Article Description
We report the first demonstration using a stable π-radical as a versatile photosensitizer for hypoxia-overcoming photodynamic therapy. After self-assembling the radical molecules into radical nanoparticles (NPs), the NPs show good water dispersibility, good biocompatibility, broad near-infrared (NIR) absorption and emission at ∼800 nm. Significantly, the radical NPs remain stable in various biological mediums, after 100 days exposure to the ambient environment, and even after long-term laser irradiation, which is superior to many reported radical-based materials. More importantly, upon 635 nm laser irradiation, sufficient superoxide radical (O2-) generation and in vitro cytotoxicity were observed addressing the most important hurdle for successful PDT in the oxygen-deficient tumor microenvironment. In addition, the radical NPs are also demonstrated to have effective in vivo PDT efficacy, and excellent biosafety.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85100940883&origin=inward; http://dx.doi.org/10.1039/d0mh01312a; http://www.ncbi.nlm.nih.gov/pubmed/34821273; https://xlink.rsc.org/?DOI=D0MH01312A; https://dx.doi.org/10.1039/d0mh01312a; https://pubs.rsc.org/en/content/articlelanding/2021/mh/d0mh01312a
Royal Society of Chemistry (RSC)
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