Balancing skeleton and functional groups in total syntheses of complex natural products: A case study of tigliane, daphnane and ingenane diterpenoids
Natural Product Reports, ISSN: 1460-4752, Vol: 38, Issue: 9, Page: 1589-1617
2021
- 25Citations
- 24Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations25
- Citation Indexes25
- 25
- CrossRef21
- Captures24
- Readers24
- 24
Review Description
Total synthesis of natural products has greatly contributed to natural product research, organic synthesis and drug discovery and development. However, in most cases, the efficiency of total synthesis is far from sufficient for direct practical industrial application. Thus, designing a concise and efficient synthetic route with balanced efforts between building the complex skeleton and introducing functional groups is highly desirable. In this critical review, we first present an introduction of this issue and a philosophical framework that cover possible synthetic approaches. Next, we have chosen the biogenetically closely related, biologically important and synthetically extremely challenging natural products, tiglianes, daphnanes and ingenanes as the particular case for the discussion, since in the past 40 years many synthetic approaches have been reported. The successes and pitfalls included therefore serve as the basis to draw some conclusions that may inspire future development in this area.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116030901&origin=inward; http://dx.doi.org/10.1039/d0np00086h; http://www.ncbi.nlm.nih.gov/pubmed/33508045; https://xlink.rsc.org/?DOI=D0NP00086H; https://dx.doi.org/10.1039/d0np00086h; https://pubs.rsc.org/en/content/articlelanding/2021/np/d0np00086h
Royal Society of Chemistry (RSC)
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