An in situ protonation-activated supramolecular self-assembly for selective suppression of tumor growth
Chemical Science, ISSN: 2041-6539, Vol: 14, Issue: 7, Page: 1724-1731
2023
- 11Citations
- 2Captures
- 1Mentions
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef7
- Captures2
- Readers2
- Mentions1
- News Mentions1
- News1
Most Recent News
New Findings on Cancer Described by Investigators at Wenzhou Medical University (An In Situ Protonation-activated Supramolecular Self-assembly for Selective Suppression of Tumor Growth)
2023 MAR 07 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Daily -- Investigators publish new report on Cancer. According to news reporting
Article Description
An in situ supramolecular self-assembly in the subcellular organelles could provide a new strategy to treat diseases. Herein, we report a protonation-activated in situ supramolecular self-assembly system in the lysosomes, which could destabilize the lysosome membrane, resulting in the selective suppression of cancer cells. In this system, pyridyl-functionalized tetraphenylethylene (TPE-Py) was protonated in the lysosomes of A549 lung cancer cells to form octahedron-like structures with cucurbit[8]uril (CB[8]), which impaired the integrity of the lysosome membrane, resulting in selective suppression of cancer cells. Moreover, its anticancer efficiency was also systematically evaluated in vivo, triggering the apoptosis of tumor tissues with ignorable effects on normal organs. Overall, the protonation-activated self-assembly in the lysosomes based on the host-guest complexation would provide a method for novel anti-cancer systems.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85147175966&origin=inward; http://dx.doi.org/10.1039/d2sc05652f; http://www.ncbi.nlm.nih.gov/pubmed/36819851; https://xlink.rsc.org/?DOI=D2SC05652F; https://dx.doi.org/10.1039/d2sc05652f; https://pubs.rsc.org/en/content/articlelanding/2023/sc/d2sc05652f
Royal Society of Chemistry (RSC)
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