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The prognostic value of C-reactive protein/albumin ratio in nasopharyngeal carcinoma: A meta-analysis

Bioscience Reports, ISSN: 1573-4935, Vol: 38, Issue: 6
2018
  • 21
    Citations
  • 0
    Usage
  • 23
    Captures
  • 1
    Mentions
  • 29
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    21
  • Captures
    23
  • Mentions
    1
    • News Mentions
      1
      • 1
  • Social Media
    29
    • Shares, Likes & Comments
      29
      • Facebook
        29

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Article Description

The C-reactive protein/albumin ratio (CRP/Alb ratio) has been reported to have promising prognostic value in several cancers. The current meta-analysis was conducted to better define the prognostic value of CRP/Alb ratio in patients with nasopharyngeal carcinoma (NPC). The Web of Science, Embase, Cochrane Library databases, and PubMed were searched up to 25 February 2018 for the information on CRP/Alb ratio and outcomes of NPC. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (95% CIs) were used to evaluate the association between CRP/Alb ratio and survival outcomes in NPC. A total of five studies with 5533 patients with NPC were included. Pooled results showed that high CRP/Alb ratio was associated with poor overall survival (OS) (HR = 1.51, 95% CI: 1.30–1.75, P<0.001) and poor distant metastasis-free survival (DMFS) (HR = 1.23, 95% CI: 1.07–1.43, P=0.005). Subgroup analyses showed that patients with higher CRP/Alb ratio have worse OS in NPC. In conclusion, elevated CRP/Alb ratio was associated with worse prognosis in patients with NPC.

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