The prognostic value of C-reactive protein/albumin ratio in nasopharyngeal carcinoma: A meta-analysis
Bioscience Reports, ISSN: 1573-4935, Vol: 38, Issue: 6
2018
- 21Citations
- 23Captures
- 1Mentions
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Metrics Details
- Citations21
- Citation Indexes21
- 21
- CrossRef13
- Captures23
- Readers23
- 23
- Mentions1
- News Mentions1
- 1
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Article Description
The C-reactive protein/albumin ratio (CRP/Alb ratio) has been reported to have promising prognostic value in several cancers. The current meta-analysis was conducted to better define the prognostic value of CRP/Alb ratio in patients with nasopharyngeal carcinoma (NPC). The Web of Science, Embase, Cochrane Library databases, and PubMed were searched up to 25 February 2018 for the information on CRP/Alb ratio and outcomes of NPC. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (95% CIs) were used to evaluate the association between CRP/Alb ratio and survival outcomes in NPC. A total of five studies with 5533 patients with NPC were included. Pooled results showed that high CRP/Alb ratio was associated with poor overall survival (OS) (HR = 1.51, 95% CI: 1.30–1.75, P<0.001) and poor distant metastasis-free survival (DMFS) (HR = 1.23, 95% CI: 1.07–1.43, P=0.005). Subgroup analyses showed that patients with higher CRP/Alb ratio have worse OS in NPC. In conclusion, elevated CRP/Alb ratio was associated with worse prognosis in patients with NPC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85056567550&origin=inward; http://dx.doi.org/10.1042/bsr20180686; http://www.ncbi.nlm.nih.gov/pubmed/30352836; https://portlandpress.com/bioscirep/article/38/6/BSR20180686/98182/The-prognostic-value-of-C-reactive-protein-albumin; https://dx.doi.org/10.1042/bsr20180686
Portland Press Ltd.
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