Prognostic factors associated with upper gastrointestinal bleeding based on the French multicenter SANGHRIA trial
Endoscopy International Open, ISSN: 2196-9736, Vol: 9, Issue: 10, Page: E1504-E1511
2021
- 3Citations
- 17Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations3
- Citation Indexes3
- Captures17
- Readers17
- 17
Article Description
Background and study aims Prognostic and risk factors for upper gastrointestinal bleeding (UGIB) might have changed overtime because of the increased use of direct oral anticoagulants and improved gastroenterological care. This study was undertaken to assess the outcomes of UGIB in light of these new determinants by establishing a new national, multicenter cohort 10 years after the first. Methods Consecutive outpatients and inpatients with UGIB symptoms consulting at 46 French general hospitals were prospectively included between November 2017 and October 2018. They were followed for at least for 6 weeks to assess 6-week rebleeding and mortality rates and factors associated with each event. Results Among the 2498 enrolled patients (mean age 68.5 [16.3] years, 67.1% men), 74.5% were outpatients and 21% had cirrhosis. Median Charlson score was 2 (IQR 1-4) and Rockall score was 5 (IQR 3-6). Within 24 hours, 83.4% of the patients underwent endoscopy. The main causes of bleeding were peptic ulcers (44.9%) and portal hypertension (18.9%). The early in-hospital rebleeding rate was 10.5%. The 6-week mortality rate was 12.5%. Predictors significantly associated with 6-week mortality were initial transfusion (OR 1.54; 95%CI 1.04-2.28), Charlson score >4 (OR 1.80; 95%CI 1.31-2.48), Rockall score >5 (OR 1.98; 95%CI 1.39-2.80), being an inpatient (OR 2.45; 95%CI 1.76-3.41) and rebleeding (OR 2.6; 95%CI 1.85-3.64). Anticoagulant therapy was not associated with dreaded outcomes. Conclusions The 6-week mortality rate remained high after UGIB, especially for inpatients. Predictors of mortality underlined the weight of comorbidities on outcomes.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116036966&origin=inward; http://dx.doi.org/10.1055/a-1508-5871; http://www.ncbi.nlm.nih.gov/pubmed/34540542; http://www.thieme-connect.de/DOI/DOI?10.1055/a-1508-5871; https://dx.doi.org/10.1055/a-1508-5871; https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1508-5871
Georg Thieme Verlag KG
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