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Hierarchical self-assembly of actin in micro-confinements using microfluidics

Biomicrofluidics, ISSN: 1932-1058, Vol: 6, Issue: 3, Page: 34120
2012
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Article Description

We present a straightforward microfluidics system to achieve step-by-step reaction sequences in a diffusion-controlled manner in quasi two-dimensional micro-confinements. We demonstrate the hierarchical self-organization of actin (actin monomers-entangled networks of filaments-networks of bundles) in a reversible fashion by tuning the Mg ion concentration in the system. We show that actin can form networks of bundles in the presence of Mg without any cross-linking proteins. The properties of these networks are influenced by the confinement geometry. In square microchambers we predominantly find rectangular networks, whereas triangular meshes are predominantly found in circular chambers. © 2012 American Institute of Physics.

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