Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer.

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The Journal of biological chemistry, ISSN: 1083-351X, Vol: 292, Issue: 10, Page: 4359

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Dalal, Kush; Roshan-Moniri, Mani; Sharma, Aishwariya; Li, Huifang; Ban, Fuqiang; Hassona, Mohamed D; Hsing, Michael; Singh, Kriti; LeBlanc, Eric; Dehm, Scott; Tomlinson Guns, Emma S; Cherkasov, Artem; Rennie, Paul S Show More Hide
American Society for Biochemistry & Molecular Biology (ASBMB)
Biochemistry, Genetics and Molecular Biology
correction description
Based on misinterpretation of the NMR spectra provided by our chemical vendor, the structure of VPC-14449 should be corrected. VPC-14449 (4-(4-(4,5-bromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine) should be replaced with VPC-14449 (4-(4-(2,4-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine). In Fig. 1A, the graphical representation of VPC-14449 should be changed to the correct structure. Our industry partner synthesized the published VPC-14449 structure (4,5-bromo) and noticed that its NMR spectrum was different from that of our VPC-14449 stock synthesized by our chemical vendor. Upon synthesizing the correct structure (2,4-bromo), it was found that the NMR spectrum of the newly synthesized 2,4-bromo compound superimposed with the NMR spectrum of the compound supplied by our chemical vendor, establishing that the original compound used in this article was the 2,4-bromo version. In conclusion, our stock of VPC-14449 supplied by our chemical vendor and used in this article is (4-(4-(2,4-dibromo-1H-imidazol-1-yl)thiazol-2-yl)morpholine). This error does not affect the results or conclusions of this work, as we simply reported the incorrect structure of our compound.