PlumX Metrics
Embed PlumX Metrics

Transfer of np(v) nitrate from gastrointestinal segments of the adult rat

International Journal of Radiation Biology, ISSN: 0955-3002, Vol: 50, Issue: 4, Page: 609-620
1986
  • 5
    Citations
  • 0
    Usage
  • 2
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The transfer of soluble Np(V) nitrate was measured in gastrointestinal segments from adult rats by two procedures: (a) instillation, in segments in which the physico-chemical form of Np might be modified by gastrointestinal factors; and (b) perfusion, in segments in which the luminal state of Np remains constant. These assays allowed accurate measurement of the Np(V) transferred from the intestine to the whole body. The amount measured was proportional to segment length and to the duration of the experiments, which lasted for periods of 0·25 to 2 h. Under these experimental conditions, hourly transfer values were about 2 per cent, both per millilitre of Np(V) solution instilled and per 10 cm of jejunum perfused. This flux is very much greater than that which may be deduced from studies in which Np was gavaged into intact rats. Intestinal transfer of Np was constant for Np concentrations ranging from 5 × 10 m to 1 × 10 m. Raising the concentration of Np(V) to more than 1 × 10 m reduced its intestinal transfer. Addition of Fe(II) also reduced it. The small intestine was the main site of Np(V) absorption, since the transfer from instilled jejunum was about 20 times that observed from the stomach, and no difference was noted between jejunal and duodenal transfer. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know