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Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

Molecular and Cellular Oncology, ISSN: 2372-3556, Vol: 6, Issue: 5, Page: e1612678
2019
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Article Description

Intrinsically disordered proteins (IDPs) do not have a well-defined structure, but they have key biological tasks in cancer development. By using the disordered cancer-related protein NUPR1 as a proof-of-concept, we have developed a new multidisciplinary approach to tackle drug-design against IDPs, using it to repurpose drugs for treating pancreatic adenocarcinoma (PDAC).

Bibliographic Details

Santofimia-Castaño, Patricia; Rizzuti, Bruno; Xia, Yi; Abian, Olga; Peng, Ling; Velázquez-Campoy, Adrián; Iovanna, Juan L; Neira, José L

Informa UK Limited

Biochemistry, Genetics and Molecular Biology

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