Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis
Journal of Cell Biology, ISSN: 0021-9525, Vol: 198, Issue: 5, Page: 847-863
2012
- 103Citations
- 151Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations103
- Citation Indexes103
- CrossRef103
- 96
- Captures151
- Readers151
- 151
Article Description
Chromokinesins are microtubule plus end-directed motor proteins that bind to chromosome arms. In Xenopus egg cell-free extracts, Xkid and Xklp1 are essential for bipolar spindle formation but the functions of the human homologues, hKID (KIF22) and KIF4A, are poorly understood. By using RNAi-mediated protein knockdown in human cells, we find that only co-depletion delayed progression through mitosis in a Mad2-dependent manner. Depletion of hKID caused abnormal chromosome arm orientation, delayed chromosome congression, and sensitized cells to nocodazole. Knockdown of KIF4A increased the number and length of microtubules, altered kinetochore oscillations, and decreased kinetochore microtubule flux. These changes were associated with failures in establishing a tight metaphase plate and an increase in anaphase lagging chromosomes. Co-depletion of both chromokinesins aggravated chromosome attachment failures, which led to mitotic arrest. Thus, hKID and KIF4A contribute independently to the rapid and correct attachment of chromosomes by controlling the positioning of chromosome arms and the dynamics of microtubules, respectively. © 2012 Wandke et al.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84866362654&origin=inward; http://dx.doi.org/10.1083/jcb.201110060; http://www.ncbi.nlm.nih.gov/pubmed/22945934; https://rupress.org/jcb/article/198/5/847/36964/Human-chromokinesins-promote-chromosome; https://dx.doi.org/10.1083/jcb.201110060
Rockefeller University Press
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