Acute and Late Bartonella henselae Murine Model Infection.

Citation data:

Vector borne and zoonotic diseases (Larchmont, N.Y.), ISSN: 1557-7759, Vol: 17, Issue: 3, Page: 206-208

Publication Year:
2017
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PMID:
28165916
DOI:
10.1089/vbz.2016.2007
Author(s):
da Silva, Marilene Neves, Vieira-Damiani, Gislaine, Ericson, Marna Elise, Gupta, Kalpna, de Almeida, Amanda Roberta, Drummond, Marina Rovani, Soares, Tania Cristina Benetti, Lania, Bruno Grosselli, Gilioli, Rovilson, Velho, Paulo Eduardo Neves Ferreira
Publisher(s):
Mary Ann Liebert Inc
Tags:
Immunology and Microbiology, Medicine
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article description
Bartonella spp. are fastidious gram-negative neglected bacilli with worldwide distribution. They are able to cause intraerythrocytic and potentially fatal infection. Cats and dogs are reservoirs of some species of these agents. Blood-sucking arthropods are potential vectors. Our aim was to evaluate the blood, skin, liver, and spleen in BALB/c mice by using molecular tests and confocal microscopy to demonstrate Bartonella henselae infection in the bloodstream and organs after 4 and 21 days of intraperitoneally injected bacterial suspension. We demonstrate that the occurrence of infection in organs precedes the detectable infection in blood. Therefore, late manifestation in blood may be another challenge in early detection and diagnosis of B. henselae infection.

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