PlumX Metrics
Embed PlumX Metrics

VYC-25L hyaluronic acid injectable gel is safe and effective for long-Term restoration and creation of volume of the lower face

Aesthetic Surgery Journal, ISSN: 1527-330X, Vol: 40, Issue: 9, Page: NP499-NP510
2020
  • 29
    Citations
  • 0
    Usage
  • 63
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Background: Juvéderm Volux (VYC-25L; Allergan plc) is an injectable hyaluronic acid gel designed to restore and create facial volume. Objectives: The aim of this study was to evaluate the safety and effectiveness of Volux for chin retrusion over 18 months and after repeat treatment. Methods: This prospective, single-blind, controlled study enrolled subjects aged ≥18 years with chin retrusion (glabellasubnasale-pogonion facial angle 145°-165°). Subjects were randomized (3:1) to Volux at study onset or 3 months later (control group), and could receive a single repeat treatment during months 18 to 24. Assessments included mean facial-angle change from baseline, Global Aesthetic Improvement Scale (GAIS) responder rates (improved/much improved), improvements in 3 subject-reported FACE-Q scales, and safety. Results: Of 132 enrolled subjects, 119 received initial Volux treatment and 89 received repeat treatment. Mean changes (95% confidence interval) in glabella-subnasale-pogonion angle from baseline for treatment and control groups, respectively, were: 1.15° (0.75°, 1.56°) and 1.16° (0.57°, 1.75°) at month 18, and 3.14° (2.68°, 3.61°) and 2.72° (1.78°, 3.66°) 1 month after repeat treatment. Investigators rated 52.5%/60.0% of treated/control subjects at month 18 and 96.9%/100% after retreatment as GAIS responders; subject-reported rates were 62.0%/64.0% and 93.8%/100%. Durable improvements in Satisfaction with Chin, Satisfaction with Lower Face and Jawline, and Psychological Well-Being were reported in 82.1%, 78.2%, and 60.3% of subjects, respectively, at month 18, and 92.3%, 93.8%, and 67.7% of subjects after retreatment. The safety profile was as expected. Conclusions: Volux injectable gel is a safe, effective, and durable alternative to surgical treatments for increasing chin projection and jaw volume, and results in high patient satisfaction.

Bibliographic Details

Ogilvie, Patricia; Benouaiche, Laurence; Philipp-Dormston, Wolfgang G; Belhaouari, Lakhdar; Gaymans, Frodo; Sattler, Gerhard; Harvey, Candice; Schumacher, Andrew

Oxford University Press (OUP)

Medicine

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know