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A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA

International Journal of Epidemiology, ISSN: 1464-3685, Vol: 46, Issue: 6, Page: 1836-1846
2017
  • 27
    Citations
  • 0
    Usage
  • 41
    Captures
  • 3
    Mentions
  • 20
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    27
  • Captures
    41
  • Mentions
    3
    • News Mentions
      3
      • 3
  • Social Media
    20
    • Shares, Likes & Comments
      20
      • Facebook
        20

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How sugar in drinks destroys the body

By Prof. Raphael Nyarkotey OBU I have observed keenly that there is a wide range of sugar desserts in the Gambia. This is a great

Article Description

Background: During the past 40 years, esophageal/gastric cardia adenocarcinoma (EA/ GCA) incidence increased in Westernized countries, but survival remained low. A parallel increase in sugar intake, which may facilitate carcinogenesis by promoting hyperglycaemia, led us to examine sugar/carbohydrate intake in association with EA/GCA incidence and survival. Methods: We pooled 500 EA cases, 529 GCA cases and 2027 controls from two US population-based case-control studies with cases followed for vital status. Dietary intake, assessed by study-specific food frequency questionnaires, was harmonized and pooled to estimate 12 measures of sugar/carbohydrate intake. Multivariable-adjusted odds ratios (ORs) and hazard ratios [95% confidence intervals (CIs)] were calculated using multinomial logistic regression and Cox proportional hazards regression, respectively. Results: EA incidence was increased by 51-58% in association with sucrose (OR=1.51, 95% CI=1.01-2.27), sweetened desserts/beverages (OR=1.55, 95% CI=1.06-2.27) and the dietary glycaemic index (OR=1.58, 95% CI=1.13-2.21). Bodymass index (BMI) and gastro-esophageal reflux disease (GERD) modified these associations (P ≤ 0.05). For associations with sucrose and sweetened desserts/beverages, respectively, the OR was elevated for BMI < 25 (OR=1.79, 95% CI=1.26-2.56 and OR=1.45, 95% CI=1.03-2.06), but not BMI≥25 (OR=1.05, 95% CI=0.76-1.44 and OR=0.85, 95% CI=0.62-1.16). The EA-glycaemic index association was elevated for BMI≥25 (OR=1.38, 95% CI=1.03-1.85), but not BMI < 25 (OR=0.88, 95% CI=0.62-1.24). The sucrose-EA association OR for GERD < weekly was 1.58 (95% CI=1.16-2.14), but for GERD≥weekly was 1.01 (95% CI=0.70-1.47). Sugar/carbohydrate measures were not associated with GCA incidence or EA/GCA survival. Conclusions: If confirmed, limiting intake of sucrose (e.g. table sugar), sweetened desserts/ beverages, and foods that contribute to a high glycaemic index, may be plausible EA risk reduction strategies.

Bibliographic Details

Li, Nan; Petrick, Jessica L; Steck, Susan E; Bradshaw, Patrick T; McClain, Kathleen M; Niehoff, Nicole M; Engel, Lawrence S; Shaheen, Nicholas J; Risch, Harvey A; Vaughan, Thomas L; Wu, Anna H; Gammon, Marilie D

Oxford University Press (OUP)

Medicine

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