Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: Implications for peripheral tolerance
International Immunology, ISSN: 0953-8178, Vol: 20, Issue: 10, Page: 1351-1360
2008
- 13Citations
- 11Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef8
- Captures11
- Readers11
- 11
Article Description
Harmful pathogenic IgG auto-antibodies are produced against desmoglein 3 (Dsg3) in pemphigus vulgaris, an autoimmune blistering disease. Dsg3 is a cadherin-type cell adhesion molecule expressed in desmosomes of the skin and mucous membranes. In AK7-transgenic mice expressing non-pathogenic AK7 IgM against Dsg3, autoreactive transgenic B cells escape from the deletion or inactivation and exist in the periphery. However, when a pathogenic anti-Dsg3 IgG1 mAb (AK23) capable of inducing blisters was injected into AK7-transgenic mice, AK7 B cells were eliminated from the bone marrow (BM) and spleen only when Dsg3 was expressed in the periphery. In contrast, non-pathogenic IgG mAbs (AK7, AK9) failed to eliminate AK7 B cells. Interestingly, the AK23-mediated elimination of mature AK7 B cells in the spleen was significantly diminished in AK7-transgenic mice on a Rag2 background while BM B cells were still eliminated, suggesting the presence of T-cell-dependent and -independent mechanisms. T cell transfer studies into AK7- Rag2 mice revealed that autoreactive B-cell elimination in the periphery requires CD4 T cells from wild-type mice but not from gld (FasL mutant) mice. The B-cell elimination was impaired in both BM and periphery when Bcl2 was over-expressed in AK7 B cells. These findings suggest that autoreactive B cells exist unless they are harmful, but once harmful or dangerous events such as tissue destruction are sensed, the mature autoreactive B cells in the periphery are eliminated via a Fas-mediated process in a CD4 T cell-dependent manner. © 2008 The Japanese Society for Immunology. 2008. All rights reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=52949149409&origin=inward; http://dx.doi.org/10.1093/intimm/dxn095; http://www.ncbi.nlm.nih.gov/pubmed/18765425; https://academic.oup.com/intimm/article-lookup/doi/10.1093/intimm/dxn095; https://dx.doi.org/10.1093/intimm/dxn095; https://academic.oup.com/intimm/article-abstract/20/10/1351/701822?redirectedFrom=fulltext
Oxford University Press (OUP)
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