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Advances in multidisciplinary therapy for meningiomas

Neuro-Oncology, ISSN: 1523-5866, Vol: 21, Issue: Suppl 1, Page: I18-I31
2019
  • 108
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Article Description

Surgery has long been established as the first-line treatment for the majority of symptomatic and enlarging meningiomas, and evidence for its success is derived from retrospective case series. Despite surgical resection, a subset of meningiomas display aggressive behavior with early recurrences that are difficult to treat. The decision to radically resect meningiomas and involved structures is balanced against the risk for neurological injury in patients. Radiation therapy has largely been used as a complementary and safe therapeutic strategy in meningiomas with evidence primarily stemming from retrospective, single-Institution reports. Two of the first cooperative group studies (RTOG 0539 and EORTC 22042) evaluating the outcomes of adjuvant radiation therapy in higher-risk meningiomas have shown promising preliminary results. Historically, systemic therapy has resulted in disappointing results in meningiomas. However, several clinical trials are under way evaluating the efficacy of chemotherapies, such as trabectedin, and novel molecular agents targeting Smoothened, AKT1, and focal adhesion kinase in patients with recurrent meningiomas.

Bibliographic Details

Priscilla K Brastianos; Evanthia Galanis; Nicholas Butowski; Jason W Chan; Ian F Dunn; Roland Goldbrunner; Christel Herold-Mende; Franziska M Ippen; Christian Mawrin; Michael W McDermott; Andrew Sloan; James Snyder; Ghazaleh Tabatabai; Marcos Tatagiba; Joerg C Tonn; Patrick Y Wen; Kenneth Aldape; Farshad Nassiri; Gelareh Zadeh; Michael D Jenkinson; David R Raleigh; Karolyn Au; Jill Barnhartz-Sloan; Wenya Linda Bi; Carlos Carlotti; Michael D Cusimano; Francesco DiMeco; Katharine Drummond; Caterina Giannini; Brent Griffith; Rintaro Hashizume; C Oliver Hanemann; Craig Horbinski; Raymond Y Huang; David James; Christine Jungk; Timothy J Kaufman; Boris Krischek; Daniel Lachance; Christian Lafougère; Ian Lee; Jeff C Liu; Yasin Mamatjan; Alireza Mansouri; Michael McDermott; David Munoz; Houtan Noushmehr; Ho-Keung Ng; Arie Perry; Farhad Pirouzmand; Laila M Poisson; Bianca Pollo; David Raleigh; Felix Sahm; Andrea Saladino; Thomas Santarius; Christian Schichor; David Schultz; Nils O Schmidt; Warren Selman; Julian Spears; Suganth Suppiah; Daniela Tirapelli; Derek Tsang; Michael A Vogelbaum; Andreas von Deimling; Tobias Walbert; Manfred Westphal; Adriana M Workewych

Oxford University Press (OUP)

Medicine; Biochemistry, Genetics and Molecular Biology

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