Acoustically active lipospheres containing paclitaxel: A new therapeutic ultrasound contrast agent
Investigative Radiology, ISSN: 0020-9996, Vol: 33, Issue: 12, Page: 886-892
1998
- 266Citations
- 77Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations266
- Citation Indexes266
- 266
- CrossRef205
- Captures77
- Readers77
- 72
- Mentions2
- References2
- 2
Article Description
RATIONALE AND OBJECTIVES. Paclitaxel-carrying lipospheres (MRX-552) were developed and evaluated as a new ultrasound contrast agent for chemotherapeutic drug delivery. METHODS. Paclitaxel was suspended in soybean oil and added to an aqueous suspension of phospholipids in vials. The headspace of the vials was replaced with perfluorobutane gas; the vials were sealed, and they were agitated at 4200 rpm on a shaking device. The resulting lipospheres containing paclitaxel were studied for concentration, size, acute toxicity in mice, and acoustic activity and drug release with ultrasound. Lipospheres containing sudan black dye were produced to demonstrate the acoustically active liposphere (AAL)-ultrasound release concept. RESULTS. Acoustically active lipospheres containing paclitaxel had a mean particle count of approximately 1 x 10 particles per mL and a mean size of 2.9 microns. Acute toxicity studies in mice showed a 10-fold reduction in toxicity for paclitaxel in AALs compared with free paclitaxel. The AALs reflected ultrasound as a contrast agent. Increasing amounts of ultrasound energy selectively ruptured the AALs and released the paclitaxel. CONCLUSIONS. Acoustically active lipospheres represent a new class of acoustically active drug delivery vehicles. Future studies will assess efficacy of AALs for ultrasound-mediated drug delivery.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0032470386&origin=inward; http://dx.doi.org/10.1097/00004424-199812000-00007; http://www.ncbi.nlm.nih.gov/pubmed/9851823; http://journals.lww.com/00004424-199812000-00007; https://dx.doi.org/10.1097/00004424-199812000-00007; https://journals.lww.com/investigativeradiology/Abstract/1998/12000/Acoustically_Active_Lipospheres_Containing.7.aspx
Ovid Technologies (Wolters Kluwer Health)
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