Vaccines for the prevention of human papillomavirus and associated gynecologic diseases: A review
Obstetrical and Gynecological Survey, ISSN: 0029-7828, Vol: 61, Issue: 6 SUPPL. 1, Page: S26-31
2006
- 24Citations
- 40Captures
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Metrics Details
- Citations24
- Citation Indexes24
- 24
- CrossRef21
- Captures40
- Readers40
- 40
Review Description
Routine vaccination programs have had a substantial impact on reducing the prevalence of a variety of infectious diseases. In light of the fact that human papillomavirus (HPV) is a prerequisite for virtually every case of cervical cancer and genital warts occurring worldwide, vaccination may be the most effective mechanism to prevent HPV infection and HPV-associated disease. HPV vaccines are created from noninfectious virus-like particles (VLPs) of the major capsid protein, L1, that closely mimic natural HPV virions. Proof-of-principle trials of monovalent vaccines that protect against high-risk HPV types such as HPV 16 or 18 have confirmed that intramuscular injection with VLPs induces the production of HPV type-specific neutralizing antibodies. A bivalent vaccine incorporating oncogenic HPV types 16 and 18 was shown to be safe, well tolerated, and 100% efficacious in preventing persistent HPV infection. A quadrivalent vaccine that protects against genital wart-causing HPV types (HPV 6 and 11) and oncogenic HPV types (HPV 16 and 18) demonstrated 100% efficacy in preventing clinical disease. Because VLP vaccines are prophylactic, vaccination before exposure to HPV will result in the greatest public health benefit; therefore, a successful vaccination program should target preadolescents and stress the importance of vaccination before sexual debut. Copyright © 2006 by Lippincott Williams & Wilkins.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33745107855&origin=inward; http://dx.doi.org/10.1097/01.ogx.0000221187.63574.5c; http://www.ncbi.nlm.nih.gov/pubmed/16729901; http://journals.lww.com/00006254-200606001-00005; https://dx.doi.org/10.1097/01.ogx.0000221187.63574.5c; https://insights.ovid.com/ShowUpgradeBrowserMessage
Ovid Technologies (Wolters Kluwer Health)
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