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Five years of steroid sparing in renal transplantation with tacrolimus and mycophenolate mofetil

Transplantation, ISSN: 0041-1337, Vol: 81, Issue: 1, Page: 125-128
2006
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Article Description

Steroid sparing with tacrolimus and mycophenolate mofetil (MMF) is associated with good short-term renal transplant outcomes. However, late allograft dysfunction and failure remain concerns. In this study, 101 consecutive patients underwent renal transplantation with tacrolimus, MMF, and 7 days of corticosteroids only. After a median follow-up of 51 months (range 36-62), overall patient survival is 97%, and overall survival with graft function is 91%. The acute rejection rate at 12 months was 19%. Late rejection was uncommon, with only three further episodes beyond 12 months. Graft function was stable during the study, with a mean creatinine of 140 μmol/L and mean estimated creatinine clearance of 57 ml/min at the end of follow-up. Six patients developed posttransplant diabetes mellitus (three cases beyond 12 months). This steroid avoidance regimen is associated with excellent medium-term patient and graft outcomes, and a low incidence of side effects. Copyright © 2006 by Lippincott Williams & Wilkins.

Bibliographic Details

Borrows, Richard; Chan, Kakit; Loucaidou, Marina; Lawrence, Christopher; Van Tromp, Jen; Cairns, Tom; Griffith, Megan; Hakim, Nadey; McLean, Adam; Palmer, Andrew; Papalois, Vassilios; Taube, David

Ovid Technologies (Wolters Kluwer Health)

Medicine

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