Cascade of HIV care and population viral suppression in a high-burden region of Kenya
AIDS, ISSN: 1473-5571, Vol: 29, Issue: 12, Page: 1557-1565
2015
- 50Citations
- 162Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations50
- Citation Indexes48
- 48
- CrossRef29
- Policy Citations2
- 2
- Captures162
- Readers162
- 162
- Mentions1
- News Mentions1
- 1
Most Recent News
“Linkage to care” among people living with HIV – definition in the era of “universal test and treat” in a sub-Sahara African setting
Magnolini Raphael a b , Senkoro Elizabeth c , Vanobberghen Fiona d e , Weisser Maja a c d e Summary BACKGROUND Prompt linkage to
Article Description
Introduction: Direct measurement of antiretroviral treatment (ART) program indicators essential for evidence-based planning and evaluation especially HIV incidence, population viral load, and ART eligibility is rare in sub-Saharan Africa. Design/methods: To measure key indicators in rural western Kenya, an area with high HIV burden, we conducted a population survey in September to November 2012 via multistage cluster sampling, recruiting everyone aged 1559 years living in 3330 randomly selected households. Consenting individuals were interviewed and tested for HIV at home. Participants testing positive were assessed for CD4 cell count and viral load, and their infections classified as either recent or long term based on Limiting Antigen Avidity assays. HIV-negative participants were tested by nucleic acid amplification to detect acute infections. Results: Of 6833 household members eligible for the study, 6076 (94.7% of all women and 81.0% of men) agreed to participate. HIV prevalence and incidence were 24.1% [95% confidence interval [CI] 23.025.2] and 1.9 new cases/100 person-years (95% CI 1.12.7), respectively. Among HIV-positive participants, 59.4% (95% CI 56.861.9) were previously diagnosed, 53.1% (95% CI 50.555.7) were receiving care, and 39.7% (95% CI 37.142.4) had viral load less than 1000 copies/ml. Applying 2013 WHO recommendations for ART initiation increased the proportion of ART-eligible people from 60.0% (based on national guidelines in place during the survey; 95% CI 57.3 62.7) to 82.0% (95% CI 79.584.5). Among HIV-positive people not receiving ART, viral load increased with decreasing CD4 cell count (500749 vs. ≤750 cells/ml, adjusted mean difference, 0.40 log10 copies/ml, 95% CI 0.200.60, P<0.01). Conclusion: This study demonstrates how population-level data can help optimize HIV programs. Based on these results, new regional programs are prioritizing diagnosis and expanding ART eligibility, key steps to reach undetectable viral load.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84942569087&origin=inward; http://dx.doi.org/10.1097/qad.0000000000000741; http://www.ncbi.nlm.nih.gov/pubmed/26244395; http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00002030-201507310-00016; https://journals.lww.com/00002030-201507310-00016; http://hdl.handle.net/10144/618885; http://dx.doi.org/10.1097/QAD.0000000000000741; https://dx.doi.org/10.1097/QAD.0000000000000741; https://journals.lww.com/aidsonline/Fulltext/2015/07310/Cascade_of_HIV_care_and_population_viral.16.aspx
Ovid Technologies (Wolters Kluwer Health)
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