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Contribution of cortical layers to human dynamic functional connectivity

bioRxiv, ISSN: 2692-8205
2023
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Contribution of cortical layers to human dynamic functional connectivity

2023 APR 26 (NewsRx) -- By a News Reporter-Staff News Editor at NewsRx Life Science Daily -- According to news reporting based on a preprint

Article Description

Transitory states of the brain, sometimes linked to particular mental disorders, can be identified by conducting a dynamic analysis of connectivity in functional magnetic resonance imaging (fMRI) data. Here, we investigated whether the connectivity between cortical laminae (in contrast to between cortical areas), can vary during the course of a resting-state scan and whether this could impact the identification of brain states in the healthy brain. We performed a sliding-window connectivity analysis of high-resolution fMRI data and found that the differential participation of the cortical layers in the overall cortical connectivity constitutes a more dynamic feature of the brain compared to region-to-region connectivity, with two main states (superficial vs. deep-laminae connectivity) fluctuating over time. Laminar connectivity restricted to the default mode network appeared relatively stable (superficial connectivity preferred), while the central executive and salience networks showed a fluctuating laminar preference. We anticipate that the dynamic analysis of connectivity focused on the different depths of the cerebral cortex could play an important role in characterizing healthy brain states as well as in identifying novel targets of psychiatric diseases.

Bibliographic Details

Patricia Pais-Roldán; Seong Dae Yun; Shukti Ramkiran; Tanja Veselinović; Irene Neuner; Markus Zimmermann; Jörg Felder; N. Jon Shah

Cold Spring Harbor Laboratory

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Immunology and Microbiology; Neuroscience; Pharmacology, Toxicology and Pharmaceutics

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