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Biosensors for the detection of cardiovascular risk markers in human serum

PRIME - 2008 PhD Research in Microelectronics and Electronics, Proceedings, Page: 25-28
2008
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Conference Paper Description

This paper presents two affinity-based biosensor implementations for the detection and quantification of cardiovascular risk proteins/markers, such as C-Reactive Protein, Myoglobin, TNF-α, Serum Amyloid, using specific antibodies. The first method is based on interdigitated microelectrodes while the other is based microarrays. The signal transduction in micro-IDEs from biological-signal to the electronic/electrical signal occurs via fringe fields and dielectric change, induced by the capture of antigens by already immobilized antibody between the microelectrodes. Being process/integration-compatible with microelectronic/fabrication technologies, this method provides many advantages for the utilization in portable and/or remote sensing applications, such as smaller size, lower power consumption, small sample consumption, disposability, etc. The other method also analyzes the capability and reliability of sandwich-type antibody micro-arrays for the detection quantification of cardiovascular risk markers, using optical scanner system for the detection of fluorescent-labeled, sandwiched-structured antibodies on the chemically modified glass substrates. Our findings in microarray study provides the advantages for lab-based detection and quantification applications such as being able to detect and quantify multiple markers at once and also better dynamic ranges over some of the commercial ELISA test-kits. © 2008 IEEE.

Bibliographic Details

Ozgur Gul; Sreenivasa S. Kallempudi; Huveyda Basaga; Ugur Sezerman; Yasar Gurbuz

Institute of Electrical and Electronics Engineers (IEEE)

Engineering

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