Cardiac source localization by means of a single moving dipole solution during endocardial pacing in an animal model.

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Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, ISSN: 1557-170X, Vol: 2009, Page: 1778-80

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Lai, Dakun; Liu, Chenguang; Eggen, Michael D; Iaizzo, Paul A; He, Bin
Institute of Electrical and Electronics Engineers (IEEE)
Biochemistry, Genetics and Molecular Biology; Engineering; Medicine
article description
The accuracy of localizing the initiation site of cardiac activation by noninvasively estimating a single moving dipole (SMD) was investigated in a swine model. Body surface potential mapping (BSPM) and intracavitary noncontact mapping (NCM) were performed simultaneously during acute left ventricular (LV) endocardial pacing. For each animal, the boundary element model was constructed from preoperative magnetic resonance images (MRI). In each pacing study, the initiation site was localized by inversely estimating the location of an SMD from BSPM data. The results were compared with the precise pacing sites recorded by the NCM system. In total, four pacing sites from two pigs were analyzed, and the averaged source localization error was 16.8 +/- 2.3 mm. The present results indicate the potential of localizing focal cardiac events by estimating single moving dipole.