Serum iron and matrix metalloproteinase-9 variations in limbs affected by chronic venous disease and venous leg ulcers
Dermatologic Surgery, ISSN: 1076-0512, Vol: 31, Issue: 6, Page: 644-649
2005
- 65Citations
- 32Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations65
- Citation Indexes64
- 64
- CrossRef36
- Policy Citations1
- Policy Citation1
- Captures32
- Readers32
- 24
Article Description
BACKGROUND. Severe chronic venous disease (CVD) is characterized by both dermal hemosiderin accumulation and matrix metalloproteinase (MMP) hyperactivation. The iron-driven pathway is one of the recognized mechanisms of MMP hyperactivation. OBJECTIVE. To investigate the potential consequences of leg hemosiderin deposits on both iron metabolism and activation of MMPs. METHODS. We contemporaneously assessed the following in the serum of the arm and ankle veins of 30 patients (C4-6) with CVD and 14 normal subjects: ferritin, transferrin, iron, percentage of transferrin iron binding capacity (%TIBC), and MMP-9. Optical microscopy examinations with Perls' staining of chronic wounds were also performed. RESULTS. Histology consistently revealed iron deposits. Serum ferritin, iron, and %TIBC were significantly increased in the legs affected by severe CVD compared with the arm of the same subjects or the controls. In addition, iron and %TIBC were significantly elevated in the legs of ulcer patients. The rate of activation of MMP-9 was significantly elevated in CVD. CONCLUSIONS. The increased iron deposition in legs affected by CVD seems to be more instable in ulcer patients, leading to iron release in the serum of the affected leg. Our data suggest the iron-driven pathway as a further mechanism for MMP hyperexpression leading to tissue lesion. © 2005 by the American Society for Dermatologic Surgery, Inc.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=22844447869&origin=inward; http://dx.doi.org/10.1097/00042728-200506000-00005; http://www.ncbi.nlm.nih.gov/pubmed/15996413; http://dx.doi.org/10.1111/j.1524-4725.2005.31611; http://journals.lww.com/00042728-200506000-00005; https://journals.lww.com/00042728-200506000-00005; https://dx.doi.org/10.1097/00042728-200506000-00005; https://journals.lww.com/dermatologicsurgery/Abstract/2005/06000/Serum_Iron_and_Matrix_Metalloproteinase_9.5.aspx
Ovid Technologies (Wolters Kluwer Health)
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