Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study.

Citation data:

Journal of neuroimaging : official journal of the American Society of Neuroimaging, ISSN: 1552-6569, Vol: 27, Issue: 6, Page: 630-636

Publication Year:
2017
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PMID:
28661060
DOI:
10.1111/jon.12454
Author(s):
Zeydan, Burcu; Deelchand, Dinesh K; Tosakulwong, Nirubol; Lesnick, Timothy G; Kantarci, Orhun H; Machulda, Mary M; Knopman, David S; Lowe, Val J; Jack, Clifford R; Petersen, Ronald C; Öz, Gülin; Kantarci, Kejal Show More Hide
Publisher(s):
Wiley-Blackwell
Tags:
Medicine
article description
Glutamate levels may be informative about the declining neuronal health in the central nervous system. We used an advanced proton MR spectroscopy ( H-MRS) protocol composed of semi-localization by adiabatic selective refocusing (sLASER) localization and FAST(EST)MAP shimming for detection of alterations in brain glutamate concentrations in patients with amnestic mild cognitive impairment.