Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study.

Citation data:

Journal of neuroimaging : official journal of the American Society of Neuroimaging, ISSN: 1552-6569, Vol: 27, Issue: 6, Page: 630-636

Publication Year:
2017
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PMID:
28661060
DOI:
10.1111/jon.12454
Author(s):
Zeydan, Burcu, Deelchand, Dinesh K, Tosakulwong, Nirubol, Lesnick, Timothy G, Kantarci, Orhun H, Machulda, Mary M, Knopman, David S, Lowe, Val J, Jack, Clifford R, Petersen, Ronald C, Öz, Gülin, Kantarci, Kejal Show More Hide
Publisher(s):
Wiley-Blackwell
Tags:
Medicine
article description
Glutamate levels may be informative about the declining neuronal health in the central nervous system. We used an advanced proton MR spectroscopy ( H-MRS) protocol composed of semi-localization by adiabatic selective refocusing (sLASER) localization and FAST(EST)MAP shimming for detection of alterations in brain glutamate concentrations in patients with amnestic mild cognitive impairment.

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