Eltrombopag, a thrombopoietin mimetic, crosses the blood-brain barrier and impairs iron-dependent hippocampal neuron dendrite development.

Citation data:

Journal of thrombosis and haemostasis : JTH, ISSN: 1538-7836, Vol: 15, Issue: 3, Page: 565-574

Publication Year:
2017
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PMID:
28005311
DOI:
10.1111/jth.13602
Author(s):
T. W. Bastian, K. A. Duck, G. C. Michalopoulos, M. J. Chen, Z.-J. Liu, J. R. Connor, L. M. Lanier, M. C. Sola-Visner, M. K. Georgieff
Publisher(s):
Wiley-Blackwell
Tags:
Medicine
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article description
Essentials Potential neurodevelopmental side effects of thrombopoietin mimetics need to be considered. The effects of eltrombopag (ELT) on neuronal iron status and dendrite development were assessed. ELT crosses the blood-brain barrier and causes iron deficiency in developing neurons. ELT blunts dendrite maturation, indicating a need for more safety studies before neonatal use.

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