Assessing the dynamic biofilm removal of sulfonated phenolics using CP-OCT

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Progress in Biomedical Optics and Imaging - Proceedings of SPIE, ISSN: 1605-7422, Vol: 10044, Page: 1004409

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Peter Rechmann, Daniel Fried, K. Englund, J. Nikrad, R. Jones
SPIE-Intl Soc Optical Eng
Physics and Astronomy, Materials Science, Medicine
conference paper description
Examining the physical mechanisms related to biofilm removal of sulfonated phenolics (SP) is difficult using conventional microscopy techniques. A custom flow cell system integrated with a real time cross polarization optical coherence tomography system investigated the dynamic speed of biofilm removal when oral multi-species biofilms are exposed to SP under sheer stress. The Near infrared 1310-nm CP-OCT system non-destructively imaged fluid immersed oral biofilms at nearly 30 frames/s. This dynamic imaging was able to determine the cohesive and adhesion related disruption of SP on oral biofilms adhering to tooth like surfaces. For multi-species biofilms that are initially grown without the presence of sucrose, the disruption of biofilms on saliva coated hydroxyapatite (HA) is dominated as a adhesive failure at the HA-biofilm interface. For multi-species biofilms that are grown in the presence of sucrose, the disruption is dominated by cohesive disruption followed by adhesive failure. This novel CP-OCT flow cell assay has the potential to examine rapid interactions between anti-biofilm agents and tooth like surfaces.

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