The mutational landscape of head and neck squamous cell carcinoma
Science, ISSN: 0036-8075, Vol: 333, Issue: 6046, Page: 1157-1160
2011
- 2,115Citations
- 1,498Captures
- 7Mentions
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations2,115
- Citation Indexes2,099
- 2,099
- CrossRef2,052
- 1,344
- Policy Citations9
- Policy Citation9
- Patent Family Citations7
- Patent Families7
- Captures1,498
- Readers1,498
- 1,438
- 59
- Mentions7
- News Mentions5
- News5
- Blog Mentions1
- Blog1
- References1
- Wikipedia1
Most Recent News
In vivo single-cell CRISPR uncovers distinct TNF programmes in tumour evolution
Nature, Published online: 17 July 2024; doi:10.1038/s41586-024-07663-y A CRISPR-based strategy for screening genes that affect clonal expansion finds that genes that are frequently mutated in squamous cell carcinoma converge on a TNF signalling module involving macrophages.
Article Description
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority exhibited a mutational profile consistent with tobacco exposure; human papillomavirus was detectable by sequencing DNA from infected tumors. In addition to identifying previously known HNSCC genes (TP53, CDKN2A, PTEN, PIK3CA, and HRAS), our analysis revealed many genes not previously implicated in this malignancy. At least 30% of cases harbored mutations in genes that regulate squamous differentiation (for example, NOTCH1, IRF6, and TP63), implicating its dysregulation as a major driver of HNSCC carcinogenesis. More generally, the results indicate the ability of large-scale sequencing to reveal fundamental tumorigenic mechanisms.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=80052158097&origin=inward; http://dx.doi.org/10.1126/science.1208130; http://www.ncbi.nlm.nih.gov/pubmed/21798893; https://facultyopinions.com/prime/718386639#eval793503526; http://dx.doi.org/10.3410/f.718386639.793503526; https://facultyopinions.com/prime/718386639#eval793495247; http://dx.doi.org/10.3410/f.718386639.793495247; https://www.science.org/doi/10.1126/science.1208130; https://dx.doi.org/10.1126/science.1208130; https://www.science.org/lookup/doi/10.1126/science.1208130; https://www.science.org/doi/abs/10.1126/science.1208130; http://www.sciencemag.org/cgi/doi/10.1126/science.1208130; http://science.sciencemag.org/content/333/6046/1157; http://science.sciencemag.org/content/333/6046/1157.abstract; http://science.sciencemag.org/content/333/6046/1157.full.pdf; http://science.sciencemag.org/lookup/doi/10.1126/science.1208130; https://science.sciencemag.org/content/333/6046/1157; https://science.sciencemag.org/content/333/6046/1157.abstract; https://science.sciencemag.org/content/sci/333/6046/1157.full.pdf; http://science.sciencemag.org/cgi/doi/10.1126/science.1208130
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