Regulation of staphylococcus aureus virulence
Gram-Positive Pathogens, Page: 669-686
2019
- 17Citations
- 253Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Book Chapter Description
Staphylococcus aureus is a Gram-positive commensal bacterium and opportunistic pathogen. The main sites of colonization are the skin and mucous membranes, and approximately 30% of the healthy adult population are colonized by S. aureus (1). Although S. aureus is primarily a commensal microbe, it has the potential to cause a wide range of diseases that can vary considerably in severity. The most common problems are skin infections, and some of the most severe are bloodstream infections, endocarditis, osteomyelitis, and necrotizing fasciitis (2). To survive and adapt to different environmental niches, S. aureus has evolved an intricate regulatory network to control virulence factor production in both a temporal and host location manner (3). The regulatory machinery and virulence factors are known as accessory genes, since they are not essential for normal growth. These accessory factors are used to establish dominance in the host and contribute to the pathogenicity of S. aureus, and they include cell surface components and proteins directly released into the extracellular environment. The functions of these molecules include adherence to host cells, evasion of host defenses, nutrient degradation, and acquisition. These accessory genetic elements are encoded directly on the chromosome and on mobile elements that include phages, plasmids, and pathogenicity islands.
Bibliographic Details
American Society for Microbiology
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