A distant upstream locus control region is critical for expression of the kit receptor gene in mast cells
Molecular and Cellular Biology, ISSN: 0270-7306, Vol: 26, Issue: 15, Page: 5850-5860
2006
- 35Citations
- 34Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations35
- Citation Indexes35
- 35
- CrossRef32
- Captures34
- Readers34
- 34
Article Description
The Kit receptor tyrosine kinase functions in hematopoiesis, melanogenesis, and gametogenesis and in interstitial cells of Cajal. We previously identified two upstream hypersensitive site (HS) clusters in mast cells and melanocytes. Here we investigated the roles of these 5′ HS sequences in Kit expression using transgenic mice carrying Kit-GFP reporter constructs. In these mice there is close correspondence between Kit-GFP reporter and endogenous Kit gene expression in most tissues analyzed. Deletion analysis defined the 5′ upstream HS cluster region as critical for Kit expression in mast cells. Furthermore, chromatin immunoprecipitation analysis in mast cells showed that H3 and H4 histone hyperacetylation and RNA polymerase II recruitment within the Kit promoter and in the 5′ HS region were associated with Kit expression. Therefore, the 5′ upstream hypersensitivity sites appear to be critical components of locus control region-mediated Kit gene activation in mast cells. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33746567854&origin=inward; http://dx.doi.org/10.1128/mcb.01854-05; http://www.ncbi.nlm.nih.gov/pubmed/16847336; https://www.tandfonline.com/doi/full/10.1128/MCB.01854-05; http://mcb.asm.org/cgi/doi/10.1128/MCB.01854-05; https://syndication.highwire.org/content/doi/10.1128/MCB.01854-05; https://dx.doi.org/10.1128/mcb.01854-05; http://mcb.asm.org/lookup/doi/10.1128/MCB.01854-05; https://mcb.asm.org/content/26/15/5850; https://mcb.asm.org/content/26/15/5850.abstract; https://mcb.asm.org/content/26/15/5850.full.pdf; http://mcb.asm.org/content/26/15/5850; https://journals.asm.org/doi/10.1128/MCB.01854-05; https://journals.asm.org/doi/abs/10.1128/MCB.01854-05; https://mcb.asm.org/content/mcb/26/15/5850.full.pdf
Informa UK Limited
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know