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Genomic Assembly of Clinical Candida glabrata (Nakaseomyces glabrata) Isolates Reveals within-Species Structural Plasticity and Association with in Vitro Antifungal Susceptibility

Microbiology Spectrum, ISSN: 2165-0497, Vol: 10, Issue: 6, Page: e0182722
2022
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Article Description

The opportunistic human pathogen Candida glabrata has become an increasingly important threat to human health, with infections globally characterized by high mortality rates and multidrug resistance. To face this threat, more efficient diagnostic and therapeutic approaches are required, underpinning research to help define the intraspecies epidemiology, genetic variability, and therefore, diagnostic and therapeutic target stability. Previous comparative genetics studies conducted on limited numbers of strains only revealed partial resolution of chromosomal settings. In this study, by combining short- and long-read genome sequencing, phenotypic characterization, and comparative genomics over a large set of strains, we detected strict relationships between large chromosomal rearrangements and phylogenetic clades, genes subjected to different selective pressures, and new sets of genes associated with resistance to antifungals. Overall, these results not only provide a fundamental contribution to our knowledge of C. glabrata evolution and epidemiology but may also lay the foundations for the future development of tailored therapeutic approaches.

Bibliographic Details

Irene Stefanini; Emily Stoakes; Houdini H. T. Wu; Li Xu-McCrae; Abid Hussain; John Moat; Christopher G. Dowson; Miruna D. David; Chrystala Constantinidou; Rebecca S. Shapiro

American Society for Microbiology

Biochemistry, Genetics and Molecular Biology; Environmental Science; Immunology and Microbiology; Medicine

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