PlumX Metrics
Embed PlumX Metrics

Myosin binding protein-C slow: An intricate subfamily of proteins

Journal of Biomedicine and Biotechnology, ISSN: 1110-7243, Vol: 2010, Page: 652065
2010
  • 27
    Citations
  • 0
    Usage
  • 37
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Review Description

Myosin binding protein C (MyBP-C) consists of a family of thick filament associated proteins. Three isoforms of MyBP-C exist in striated muscles: cardiac, slow skeletal, and fast skeletal. To date, most studies have focused on the cardiac form, due to its direct involvement in the development of hypertrophic cardiomyopathy. Here we focus on the slow skeletal form, discuss past and current literature, and present evidence to support that: (i) MyBP-C slow comprises a subfamily of four proteins, resulting from complex alternative shuffling of the single MyBP-C slow gene, (ii) the four MyBP-C slow isoforms are expressed in variable amounts in different skeletal muscles, (iii) at least one MyBP-C slow isoform is preferentially found at the periphery of M-bands and (iv) the MyBP-C slow subfamily may play important roles in the assembly and stabilization of sarcomeric M-and A-bands and regulate the contractile properties of the actomyosin filaments. © 2010 M. A. Ackermann and A. Kontrogianni-Konstantopoulos.

Bibliographic Details

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know