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Primary carcinoma of the fallopian tube: A review of a single institution experience of 8 cases

The Scientific World Journal, ISSN: 1537-744X, Vol: 2014, Page: 630731
2014
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Article Description

Aims and Objectives. To evaluate the clinicopathologic features, response to cytoreductive surgery and adjuvant platinum-based chemotherapy with or without paclitaxel. Materials and Methods. A retrospective observational study of 8 women with a histopathologic diagnosis of primary fallopian tube carcinoma (PFTC) from January 2000 to February 2013. Results. 4/8 (50%) of the women were in the early stage and an intraoperative frozen section was 100% effective in identifying fallopian tube carcinoma and then a staging laparotomy was performed. All 4/8 cases in the early stage had received and responded to single agent carboplatin and all are alive without clinical, radiological, or biochemical evidence of recurrence at the end of 2 years and the longest survivor has completed 13 years. Primary optimal cytoreductive surgery was achievable in 3/4 (75%) in advanced disease. All showed response to adjuvant paclitaxel and carboplatin (T+C), but all had succumbed to the disease following recurrence with mean progression-free survival of 19 months (range 15-21 months) and mean overall survival of 27 months (range 22-36 months). Conclusion. The pivotal role played by a frozen section in diagnosing PFTC which is rare needs to be reemphasized, therefore justifying a primary staging laparotomy in an early stage. Prolonged survival observed in this group following an optimum tailored adjuvant single agent carboplatin is worth noting. © 2014 Shakuntala P. Nanaiah et al.

Bibliographic Details

Nanaiah, Shakuntala P; Rathod, Praveen S; Rajkumar, Namrata N; Kundargi, Rajshekar; Subbian, Anbukkani; Ramachandra, Pallavi V; Krishnappa, Shobha; Narayan, Abhilasha; Devi, Uma K; Uttamchand, Bafna D

Hindawi Limited

Biochemistry, Genetics and Molecular Biology; Environmental Science

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