Primary carcinoma of the fallopian tube: A review of a single institution experience of 8 cases
The Scientific World Journal, ISSN: 1537-744X, Vol: 2014, Page: 630731
2014
- 9Citations
- 7Captures
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Metrics Details
- Citations9
- Citation Indexes9
- CrossRef3
- Captures7
- Readers7
Article Description
Aims and Objectives. To evaluate the clinicopathologic features, response to cytoreductive surgery and adjuvant platinum-based chemotherapy with or without paclitaxel. Materials and Methods. A retrospective observational study of 8 women with a histopathologic diagnosis of primary fallopian tube carcinoma (PFTC) from January 2000 to February 2013. Results. 4/8 (50%) of the women were in the early stage and an intraoperative frozen section was 100% effective in identifying fallopian tube carcinoma and then a staging laparotomy was performed. All 4/8 cases in the early stage had received and responded to single agent carboplatin and all are alive without clinical, radiological, or biochemical evidence of recurrence at the end of 2 years and the longest survivor has completed 13 years. Primary optimal cytoreductive surgery was achievable in 3/4 (75%) in advanced disease. All showed response to adjuvant paclitaxel and carboplatin (T+C), but all had succumbed to the disease following recurrence with mean progression-free survival of 19 months (range 15-21 months) and mean overall survival of 27 months (range 22-36 months). Conclusion. The pivotal role played by a frozen section in diagnosing PFTC which is rare needs to be reemphasized, therefore justifying a primary staging laparotomy in an early stage. Prolonged survival observed in this group following an optimum tailored adjuvant single agent carboplatin is worth noting. © 2014 Shakuntala P. Nanaiah et al.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896344884&origin=inward; http://dx.doi.org/10.1155/2014/630731; http://www.ncbi.nlm.nih.gov/pubmed/24696653; http://www.hindawi.com/journals/tswj/2014/630731/; https://dx.doi.org/10.1155/2014/630731; https://www.hindawi.com/journals/tswj/2014/630731/
Hindawi Limited
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