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Exercise-induced increase in lipid peroxidation in patients with chronic heart failure: Relation to exercise intolerance

Cardiology, ISSN: 0008-6312, Vol: 108, Issue: 4, Page: 307-313
2007
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Article Description

Background: Little is known about the relationship between exercise intolerance and lipid peroxidation in chronic heart failure (CHF) patients. This study was designed to investigate the relationship between exercise-induced plasma malondialdehyde (MDA) changes in CHF patients and to determine whether there is any association between plasma MDA levels and exercise capacity assessed by cardiopulmonary exercise testing. Methods: Cardiopulmonary exercise testing was applied to 31 CHF patients (16 ischemic, 15 idiopathic) and controls. Rest and peak exercise blood samples were analyzed for MDA. Results: Patients with CHF had elevation of plasma MDA levels during exercise compared with controls (p < 0.001 vs. p = 0.588). MDA change remained significant both in ischemic and idiopathic cardiomyopathy groups (p < 0.05 and p < 0.01, respectively). ΔMDA (peak exercise MDA - rest MDA) showed significant inverse correlation with peak oxygen consumption in patients with CHF. Conclusion: Lipid peroxidation is increased in patients with CHF during exercise regardless of etiology, and this increase is inversely related to oxygen consumption. Copyright © 2007 S. Karger AG.

Bibliographic Details

Sayar, Nurten; Terzi, Sait; Yilmaz, Hale Yaka; Tangurek, Burak; Bilsel, Tuba; Cakmak, Nazmiye; Orhan, Lutfullah; Emre, Ayse; Ciloglu, Figen; Peker, Ismail; Yesilcimen, Kemal

S. Karger AG

Medicine

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