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Design and methodologies of the postconditioning during coronary angioplasty in acute myocardial infarction (POST-AMI) trial

Cardiology, ISSN: 0008-6312, Vol: 116, Issue: 2, Page: 110-116
2010
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Article Description

Background: Reperfusion remains the definitive treatment for acute myocardial infarction (AMI), but restoring blood flow carries the potential to exacerbate the ischemia-related injury. Postconditioning might modify reperfusion-induced adverse events. Study Design: The POSTconditioning during Coronary Angioplasty in Acute Myocardial Infarction (POST-AMI) trial is a single-center, prospective, randomized study, with a planned inclusion of 78 patients with ST-elevation AMI. Patients will be randomly assigned to the postconditioning arm [primary angioplasty (PA) and stenting followed by brief episodes of ischemia-reperfusion early after recanalization] or non-postconditioning arm. All patients will be treated medically according to current international guidelines, including glycoprotein IIb/IIIa inhibitors before PA. The primary end point is to evaluate whether postconditioning, compared to plain PA, reduces infarct size estimated by cardiac magnetic resonance (CMR) at 30 ± 10 days after the AMI. Secondary end points are microvascular obstruction observed at CMR, ST-segment resolution, angiographic myocardial blush grade <2, non-sustained/sustained ventricular tachycardia in the 48 h following PA, left ventricular remodeling and function at follow-up CMR, and the reduction of major adverse cardiac events at 30 days and 6 months. Conclusion: The POST-AMI trial will evaluate the usefulness of postconditioning in limiting infarct size during the early and late phases after AMI. © 2010 S. Karger AG.

Bibliographic Details

Tarantini, Giuseppe; Favaretto, Enrico; Napodano, Massimo; Perazzolo Marra, Martina; Cacciavillani, Luisa; Babuin, Luciano; Giovagnoni, Andrea; Renda, Pietro; De Biasio, Valeria; Plebani, Mario; Mion, Monica; Zaninotto, Martina; Mistrorigo, Flavio; Panfili, Marco; Isabella, Giambattista; Bilato, Claudio; Iliceto, Sabino

S. Karger AG

Medicine

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