Expression of arachidonate metabolism enzymes and receptors in nasal polyps of aspirin-hypersensitive asthmatics.

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International archives of allergy and immunology, ISSN: 1423-0097, Vol: 157, Issue: 4, Page: 354-62

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Adamusiak, Anna M, Stasikowska-Kanicka, Olga, Lewandowska-Polak, Anna, Danilewicz, Marian, Wagrowska-Danilewicz, Malgorzata, Jankowski, Andrzej, Kowalski, Marek L, Pawliczak, Rafal
S. Karger AG
Medicine, Immunology and Microbiology
article description
The pathogenesis of rhinosinusitis in aspirin-exacerbated airway disease is closely linked to the disequilibrium in arachidonic acid metabolism. Although considerable amounts of data concerning impaired eicosanoid production are available, the precise mechanism and pathogenesis of the disease are still unknown. The aim of the present study was to assess the expression of enzymes belonging to the arachidonic acid cascade and receptors for arachidonate derivative metabolites in nasal polyps from aspirin- hypersensitive (AH) and aspirin-tolerant (AT) patients with rhinosinusitis.

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