Tolerogenic pDCs: Spotlight on Foxo3
Journal of Clinical Investigation, ISSN: 0021-9738, Vol: 121, Issue: 4, Page: 1247-1250
2011
- 7Citations
- 20Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef7
- Captures20
- Readers20
- 20
Article Description
Cancer creates a peculiar inflammatory environment enriched for transcription factors with a negative influence on adaptive immunity. In this issue of the JCI, Watkins and colleagues identify Foxo3 as a master regulator of the tolerogenic program in tumor-associated, plasmacytoid DCs (pDCs). Foxo3 enables pDCs to induce tolerance in tumor antigen-specific CD8 T cells, turning them into regulatory lymphocytes capable of inhibiting nearby CD8 T lymphocytes. Provision of tumor-specific CD4 T helper cells interrupts this circuit by inhibiting Foxo3 expression and fully licensing the antigen-presenting ability of pDCs. These data identify a new target for therapeutic intervention and provide insight into the transcription factor interplay in myeloid cells recruited to the cancer microenvironment. Copyright © 2011, The American Society for Clinical Investigation.
Bibliographic Details
American Society for Clinical Investigation
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