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The Influence of Parenteral Glutamine and Branched-Chain Amino Acids on Total Parenteral Nutrition—Induced Atrophy of the Gut

Journal of Parenteral and Enteral Nutrition, ISSN: 1941-2444, Vol: 17, Issue: 4, Page: 348-354
1993
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Article Description

We tested the hypothesis that the provision of glutamine and branched-chain amino acids would reverse the gut atrophy that accompanies parenteral nutrition. Three hundred seventy-five rats were randomized into 15 groups to receive either conventional parenteral nutrition, rat food, glutamine-enriched parenteral nutrition (0.5% to 2.5%), branched-chain amino acid-enriched parenteral nutrition (0.8% to 2.0%), or glutamine plus branched-chain amino acid-enriched parenteral nutrition (0.5%/0.4% to 1.25%/1/0%). When compared with effects of conventional parenteral nutrition, the infusion of either glutamine or branched-chain amino acids partially reversed, in a dose-dependent manner, atrophy of the small bowel as assessed by gut weight (p < 0.05), mucosal weight (p < 0.05), villous height (p < 0.05), crypt cell production rate (p < 0.05), and mucosal protein concentration (p < 0.05). There was no effect on the large bowel. These results suggest that the parenteral infusion of either glutamine or branched-chain amino acids partially reverses the small-bowel atrophy that is associated with the infusion of solutions of conventional parenteral nutrients. © 1993, Sage Publications. All rights reserved.

Bibliographic Details

http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027197746&origin=inward; http://dx.doi.org/10.1177/0148607193017004348; http://www.ncbi.nlm.nih.gov/pubmed/8271360; https://aspenjournals.onlinelibrary.wiley.com/doi/10.1177/0148607193017004348; https://dx.doi.org/10.1177/0148607193017004348; https://aspenjournals.onlinelibrary.wiley.com/doi/abs/10.1177/0148607193017004348; https://research-repository.uwa.edu.au/en/publications/7a315354-cc26-4add-b41c-c479066a53c3; https://research-repository.uwa.edu.au/en/publications/the-influence-of-parenteral-glutamine-and-branched-chain-amino-ac; http://research-repository.uwa.edu.au/en/publications/the-influence-of-parenteral-glutamine-and-branched-chain-amino-acids-on-total-parenteral-nutritioninduced-atrophy-of-the-gut(7a315354-cc26-4add-b41c-c479066a53c3).html; http://pen.sagepub.com/cgi/doi/10.1177/0148607193017004348; http://pen.sagepub.com/content/17/4/348.abstract; http://pen.sagepub.com/content/17/4/348.full.pdf; http://pen.sagepub.com/content/17/4/348; https://research-repository.uwa.edu.au/en/publications/the-influence-of-parenteral-glutamine-and-branched-chain-amino-acids-on-total-parenteral-nutritioninduced-atrophy-of-the-gut(7a315354-cc26-4add-b41c-c479066a53c3).html; http://pen.sagepub.com/lookup/doi/10.1177/0148607193017004348; https://onlinelibrary.wiley.com/doi/abs/10.1177/0148607193017004348; https://onlinelibrary.wiley.com/doi/full/10.1177/0148607193017004348; https://onlinelibrary.wiley.com/doi/pdf/10.1177/0148607193017004348

Cameron Platell; Rosalie Mccauley; Ross Mcculloch; John Hall

Wiley

Medicine; Nursing

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