Severe loss of invariant NKT cells exhibiting anti–HTLV-1 activity in patients with HTLV-1–associated disorders
Blood, ISSN: 0006-4971, Vol: 114, Issue: 15, Page: 3208-3215
2009
- 44Citations
- 32Captures
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Metrics Details
- Citations44
- Citation Indexes44
- 44
- CrossRef30
- Captures32
- Readers32
- 32
Article Description
Invariant natural killer T (iNKT) cells are unique T cells that regulate the immune response to microbes, cancers, and autoimmunity. We assessed the characteristics of iNKT cells from persons infected with human T-lymphotropic virus type 1 (HTLV-1). Whereas most infected persons remain asymptomatic carriers (ACs) throughout their lives, a small proportion, usually with high equilibrium proviral loads,develop 2 diseases: HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia (ATL). We demonstrated that the frequency of iNKT, NK, and dendritic cells in the peripheral blood of HAM/TSP and ATL patients is decreased. We also observed an inverse correlation between the iNKT cell frequency and the HTLV-1 proviral load in the peripheral blood of infected persons. Notably, in vitro stimulation of peripheral blood cells with α-galactosylceramide led to an increase in the iNKT cell number and a subsequent decrease in the HTLV-1–infected T-cell number in samples from ACs but not HAM/TSP or ATL patients. Our results suggest that iNKT cells contribute to the immune defense against HTLV-1, and iNKT-cell depletion plays an important role in the pathogenesis of HAM/TSP and ATL. Therefore, iNKT cell–based immunotherapy may be an effective strategy for preventing these HTLV-1–associated disorders.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0006497120367963; http://dx.doi.org/10.1182/blood-2009-02-203042; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=70350433785&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/19666871; https://facultyopinions.com/prime/1164414#eval626159; http://dx.doi.org/10.3410/f.1164414.626159; https://ashpublications.org/blood/article/114/15/3208/124908/Severe-loss-of-invariant-NKT-cells-exhibiting; https://dx.doi.org/10.1182/blood-2009-02-203042; https://ashpublications.org/blood/article-pdf/114/15/3208/1316856/zh804109003208.pdf; http://f1000.com/1164414#eval626159; http://www.bloodjournal.org/content/114/15/3208; http://www.bloodjournal.org/content/114/15/3208.abstract; http://www.bloodjournal.org/content/114/15/3208.full.pdf; http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-02-203042; http://www.bloodjournal.org/content/bloodjournal/114/15/3208.full.pdf
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