Caspases as prognostic markers and mortality predictors in acute organophosphorus poisoning
Journal of Genetic Engineering and Biotechnology, ISSN: 1687-157X, Vol: 18, Issue: 1, Page: 10
2020
- 8Citations
- 25Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef7
- Captures25
- Readers25
- 25
- Mentions1
- News Mentions1
- News1
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Article Description
Organophosphorus (OP) compounds have been widely available for decades in agriculture for crop protection and as cheap pest controllers, which increases the rate of exposure and poisoning cases. Using serum cholinesterase as prognostic markers for the acute OP toxicity is controversial; therefore, we aim to find out prognostic biomarkers that best correlate with mortality and outcomes of patients with acute OP toxicity. Levels of serum oxidative stress biomarkers (malondialdehyde (MDA) and total antioxidant capacity (TAC)) and activity of the apoptotic biomarkers (caspase 3 and caspase 9) and pseudo-cholinesterase (p.ChE) were performed. Also, we evaluated the apoptotic capacity through determining the genotoxic effects and chromosomal abnormalities among OP intoxicated patients. We found the activity of caspases and serum MDA and TAC were significantly increased after OP poisoning and decreased after the appropriate atropine and oxime treatment course. The ROC curve suggested caspases as mortality and outcome predictive markers for acute OP poisoning patients. However, OP poisoning cases before treatment showed significant DNA damage, and they did not show any chromosomal aberration. The mentioned results strongly suggest apoptotic-related markers (caspase 3, caspase 9) as prognostic markers for evaluation of the treatment, outcomes, and mortality rate in the acute OP toxicity patients.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1687157X23005899; http://dx.doi.org/10.1186/s43141-020-00024-y; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85083309041&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32281011; https://linkinghub.elsevier.com/retrieve/pii/S1687157X23005899; https://dx.doi.org/10.1186/s43141-020-00024-y
Elsevier BV
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