Developing a 670k genotyping array to tag ~2M SNPs across 24 horse breeds.

Citation data:

BMC genomics, ISSN: 1471-2164, Vol: 18, Issue: 1, Page: 565

Publication Year:
2017
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Repository URL:
https://doi.org/10.1186/s12864-017-3943-8
PMID:
28750625
DOI:
10.1186/s12864-017-3943-8
Author(s):
Schaefer, Robert J; Schubert, Mikkel; Bailey, Ernest; Bannasch, Danika L; Barrey, Eric; Bar-Gal, Gila Kahila; Brem, Gottfried; Brooks, Samantha A; Distl, Ottmar; Fries, Ruedi; Finno, Carrie J; Gerber, Vinzenz; Haase, Bianca; Jagannathan, Vidhya; Kalbfleisch, Ted; Leeb, Tosso; Lindgren, Gabriella; Lopes, Maria Susana; Mach, Núria; da Câmara Machado, Artur; MacLeod, James N; McCoy, Annette; Metzger, Julia; Penedo, Cecilia; Polani, Sagi; Rieder, Stefan; Tammen, Imke; Tetens, Jens; Thaller, Georg; Verini-Supplizi, Andrea; Wade, Claire M; Wallner, Barbara; Orlando, Ludovic; Mickelson, James R; McCue, Molly E Show More Hide
Publisher(s):
Springer Nature
Tags:
Biochemistry, Genetics and Molecular Biology; Equine genomics; Whole genome sequence; SNP-tagging; SNP chip; Variant recalibration; SNP discovery; SNP informativeness; SNP validation; Linkage disequilibrium; Genetics and Genomics; Large or Food Animal and Equine Medicine
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article description
To date, genome-scale analyses in the domestic horse have been limited by suboptimal single nucleotide polymorphism (SNP) density and uneven genomic coverage of the current SNP genotyping arrays. The recent availability of whole genome sequences has created the opportunity to develop a next generation, high-density equine SNP array.