Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America.

Citation data:

Pediatric rheumatology online journal, ISSN: 1546-0096, Vol: 15, Issue: 1, Page: 50

Publication Year:
2017
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PMID:
28610606
DOI:
10.1186/s12969-017-0174-0
Author(s):
C. H. Spencer; K. Rouster-Stevens; H. Gewanter; G. Syverson; R. Modica; K. Schmidt; H. Emery; C. Wallace; S. Grevich; K. Nanda; Y. D. Zhao; S. Shenoi; S. Tarvin; S. Hong; C. Lindsley; J. E. Weiss; M. Passo; K. Ede; A. Brown; K. Ardalan; W. Bernal; S. Kim; M. L. Stoll; B. Lang; A. M. Huber; R. Carrasco; C. Agaiar; L. Feller; H. Bukulmez; R. Vehe; H. Kim; H. Schmeling; D. Gerstbacher; M. Hoeltzel; B. Eberhard; R. Sundel; A. Patwardhan; Leslie Abramson; Dania Basodan; Johanna Chang; Megan Curran; Kyla Driest; Polly Ferguson; Daniel Horton; Kristin Houghton; Maria Ibarra; Esra Meidan; Marc Natter; Miriam Parsa; Reshma Patel; Sarah Ringold; Tova Ronis; Ken Schikler; Bacha Shaham; Elizabeth Stringer; Hemalatha Srinivasahu; Cagri Toruner; Mary Toth; Dawn Wahezi Show More Hide
Publisher(s):
Springer Nature
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Medicine
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article description
The prognosis of children with juvenile dermatomyositis (JDM) has improved remarkably since the 1960's with the use of corticosteroid and immunosuppressive therapy. Yet there remain a minority of children who have refractory disease. Since 2003 the sporadic use of biologics (genetically-engineered proteins that usually are derived from human genes) for inflammatory myositis has been reported. In 2011-2016 we investigated our collective experience of biologics in JDM through the Childhood Arthritis and Rheumatology Research Alliance (CARRA).