DNA-binding sequence specificity of DUX4.

Citation data:

Skeletal muscle, ISSN: 2044-5040, Vol: 6, Issue: 1, Page: 8

Publication Year:
2016
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PMID:
26823969
DOI:
10.1186/s13395-016-0080-z
PMCID:
PMC4730607
Author(s):
Zhang, Yu; Lee, John K; Toso, Erik A; Lee, Joslynn S; Choi, Si Ho; Slattery, Matthew; Aihara, Hideki; Kyba, Michael
Publisher(s):
Springer Nature
Tags:
Medicine; Biochemistry, Genetics and Molecular Biology
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article description
Misexpression of the double homeodomain transcription factor DUX4 results in facioscapulohumeral muscular dystrophy (FSHD). A DNA-binding consensus with two tandem TAAT motifs based on chromatin IP peaks has been discovered; however, the consensus has multiple variations (flavors) of unknown relative activity. In addition, not all peaks have this consensus, and the Pitx1 promoter, the first DUX4 target sequence mooted, has a different TAAT-rich sequence. Furthermore, it is not known whether and to what extent deviations from the consensus affect DNA-binding affinity and transcriptional activation potential.