DNA-binding sequence specificity of DUX4.
- Citation data:
Skeletal muscle, ISSN: 2044-5040, Vol: 6, Issue: 1, Page: 8
- Publication Year:
- Medicine; Biochemistry, Genetics and Molecular Biology
- Most Recent Tweet View All Tweets
Misexpression of the double homeodomain transcription factor DUX4 results in facioscapulohumeral muscular dystrophy (FSHD). A DNA-binding consensus with two tandem TAAT motifs based on chromatin IP peaks has been discovered; however, the consensus has multiple variations (flavors) of unknown relative activity. In addition, not all peaks have this consensus, and the Pitx1 promoter, the first DUX4 target sequence mooted, has a different TAAT-rich sequence. Furthermore, it is not known whether and to what extent deviations from the consensus affect DNA-binding affinity and transcriptional activation potential.