Ca2+ signals coordinate zygotic polarization and cell cycle progression in the brown alga Fucus serratus
Development, ISSN: 0950-1991, Vol: 135, Issue: 12, Page: 2173-2181
2008
- 32Citations
- 48Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations32
- Citation Indexes32
- CrossRef32
- 27
- Captures48
- Readers48
- 48
Article Description
Zygotes of the fucoid brown algae provide excellent models for addressing fundamental questions about zygotic symmetry breaking. Although the acquisition of polarity is tightly coordinated with the timing and orientation of the first asymmetric division - with zygotes having to pass through a G1/5-phase checkpoint before the polarization axis can be fixed -the mechanisms behind the interdependence of polarization and cell cycle progression remain unclear. In this study, we combine in vivo Ca imaging, single cell monitoring of S-phase progression and multivariate analysis of high-throughput intracellular Call buffer loading to demonstrate that Ca signals coordinate polarization and cell cycle progression in the Fucus serratus zygote. Consistent with earlier studies on this organism, and in contrast to animal models, we observe no fast Ca wave following fertilization. Rather, we show distinct slow localized Call elevations associated with both fertilization and S-phase progression, and we show that both S-phase and zygotic polarization are dependent on pre-S-phase Ca increases. Surprisingly, this Ca requirement cannot be explained by co-dependence on a single G1/S-phase checkpoint, as S phase and zygotic polarization are differentially sensitive to pre-S-phase Ca elevations and can be uncoupled. Furthermore, subsequent cell cycle progression through M phase is independent of localized actin polymerization and zygotic polarization. This absence of a morphogenesis checkpoint, together with the observed Ca-dependences of S phase and polarization, show that the regulation of zygotic division in the brown algae differs from that in other eukaryotic model systems, such as yeast and Drosophila.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=47649115071&origin=inward; http://dx.doi.org/10.1242/dev.017558; http://www.ncbi.nlm.nih.gov/pubmed/18480164; https://journals.biologists.com/dev/article/135/12/2173/64750/Ca2-signals-coordinate-zygotic-polarization-and; https://dx.doi.org/10.1242/dev.017558; https://dev.biologists.org/content/135/12/2173
The Company of Biologists
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